Rancho Biosciences

Independent Bioinformatics Consultant

March 2018 – September 2020

  • Subcontracted out for project-based tasks for various pharmaceutical organizations (Eg. Takeda, Celgene)
  • Data Curation of health science data, including genotype/phenotype data, questionnaires, biomarker, and imaging data
  • R scripting for optimization and automation of data curation tasks to support data curation team
  • Report and proposal writing using Rmarkdown
  • Bioinformatics analysis, data visualization (ggplot2)
  • PostgreSQL database design & development, assisting others with SQL queries
  • R Shiny App Development
  • Pipeline and platform scripting using AWS EC2/S3, bash scripting, and R
  • Data Curation of health science data, including genotype and phenotype data, questionnaires, biomarker, and imaging data

GenomeDx Biosciences (now Veracyte), Vancouver, BC. Canada.

Bioinformatician

November 2015 – January 2018

  • Quality control and data management for over 50 research studies and clinical trials on Prostate, Bladder, and Breast Cancer
  • Provided support for the company’s main product, Decipher, a 22-biomarker random forest signature for predicting likelihood of metastasis on Affymetrix gene expression microarray data processed from FFPE prostate resection and biopsy samples
  • Database administration for a PostgreSQL research database containing data from 28,000 patients across 50+ studies
  • Helped implement the first version of the Genomic Research Information Database (GRID) project which ran 50+ ML classifiers on every microarray and generated patient reports
  • Cloud-based infrastructure pipeline design & development
  • Curation and analysis of clinical, wetlab, and genomic data
  • Software Testing & Quality Assurance
  • SOP Documentation for Quality Control Metrics
  • Provided support on projects for CLIA validation
  • Data preprocessing, normalization & standardization
  • Machine Learning, classifier discovery & validation using supervised and unsupervised learning methods

Alberta Children’s Hospital, Calgary, AB. Canada.

Bioinformatics Support Intern

June 2015 – August 2015

  • Responsible for updating, maintaining, and developing tools on a Galaxy server for variant analysis of Illumina MiSeq (NGS) data for genetic diagnostics
  • Provided general tech support to the molecular diagnostics laboratory
  • Programmed with Perl and Bash, integrated Perl scripts with Galaxy using XML

Bieda Lab, Calgary, AB. Canada.

Bioinformatics Researcher

May 2014 – September 2014

  • Wrote programs in R to analyze gene expression microarray data in cancer tumor cells for pharmacogenomic applications
  • Worked on methods of visualizing gene expression microarray data through heatmaps and histograms for easy interpretation using R/Bioconductor graphical packages
  • Collaborated on the development of a ChIP-seq analysis pipeline, wrote programs in R and Bash and integrated them with the Kepler Scientific Workflow System